Is it Time to Re-write the Textbooks on Insulin and Obesity? Part II
A new paper published on December 6th in the journal Science once again tackles the question of whether elevated insulin drives the development of obesity (1). Mice were generated that lack Jun kinases 1 and 2 specifically in immune cells, impairing their ability to produce inflammation while having very few off-target effects. These mice do not become insulin resistant when placed on a fattening diet, and their insulin levels do not increase one iota. Are they protected from obesity? People who read the last post should know the answer already.
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Does "Metabolically Healthy Obesity" Exist?
Obesity is strongly associated with metabolic alterations and negative health outcomes including diabetes, cardiovascular disease, and some types of cancer (1, 2, 3, 4). Excess body fat is one of the primary causes of preventable health problems and mortality in the United States and many other affluent nations, ranking in importance with cigarette smoking and physical inactivity. Obesity is thought to contribute to disease via the metabolic disturbances it causes, including excess glucose and lipids in the circulation, dysregulated hormone activity including insulin and leptin, and inflammatory effects. This immediately raises two questions:
Does metabolically healthy obesity exist?
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- Does metabolically healthy obesity exist?
- If so, are metabolically healthy obese people at an elevated risk of disease and death?
Does metabolically healthy obesity exist?
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60 Minutes Report on the Flavorist Industry
A reader sent me a link to a recent CBS documentary titled "Tweaking Tastes and Creating Cravings", reported by Morley Safer.
Safer describes the "flavorist" industry, entirely dedicated to crafting irresistible odors for the purpose of selling processed and restaurant food. They focused on the company Givaudin. Dr. David Kessler, author of The End of Overeating, makes an appearance near the end.
Here are a few notable quotes:
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Safer describes the "flavorist" industry, entirely dedicated to crafting irresistible odors for the purpose of selling processed and restaurant food. They focused on the company Givaudin. Dr. David Kessler, author of The End of Overeating, makes an appearance near the end.
Here are a few notable quotes:
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