A new paper published on December 6th in the journal Science once again tackles the question of whether elevated insulin drives the development of obesity (1). Mice were generated that lack Jun kinases 1 and 2 specifically in immune cells, impairing their ability to produce inflammation while having very few off-target effects. These mice do not become insulin resistant when placed on a fattening diet, and their insulin levels do not increase one iota. Are they protected from obesity? People who read the last post should know the answer already.
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